SCHEMBL19632993

SCHEMBL19632993

C=CCC1(F)CC1Cc1nnc2c(Cl)c(-c3cccc4cccnc34)ccn12

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 20/20 0.51
KCNH2 Q12809 7/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19632918 0.74 GRM2 (0.77) GRM2KCNH2
SCHEMBL19633003 0.68 GRM2 (1.00) GRM2KCNH2
SCHEMBL24017757 0.66 GRM2 (0.68) GRM2KCNH2
SCHEMBL19633110 0.65 GRM2 (0.74) GRM2KCNH2
SCHEMBL24017776 0.65 GRM2 (0.63) GRM2KCNH2
SCHEMBL19633074 0.64 GRM2 (1.00) GRM2KCNH2
SCHEMBL19632909 0.62 GRM2 (0.55) GRM2KCNH2
SCHEMBL19632987 0.61 GRM2 (0.52) GRM2KCNH2
SCHEMBL24017764 0.61 GRM2 (0.55) GRM2KCNH2
SCHEMBL19633184 0.61 GRM2 (0.55) GRM2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017198180-A1 FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF 中国科学院上海药物研究所 2017-11-23 WO disclosed