Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19632913 | 0.90 | GRM2 (0.44) | GRM2HTR2ASLC6A3CYP2C9CYP2C19 | |
| SCHEMBL20842383 | 0.88 | GRM2 (0.47) | GRM2SLC6A3CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL21084285 | 0.87 | GRM2 (0.51) | GRM2HTR2ASLC6A3CYP2C9CYP2C19 | |
| SCHEMBL19632915 | 0.81 | GRM2 (0.48) | GRM2SLC6A3CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL19632911 | 0.79 | GRM2 (0.52) | GRM2HTR2ASLC6A3CYP2C9CYP2C19 | |
| SCHEMBL19632597 | 0.77 | GRM2 (0.52) | GRM2SLC6A3CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL19633226 | 0.77 | GRM2 (0.52) | GRM2HTR2ASLC6A3CYP2C9CYP2C19 | |
| SCHEMBL19633195 | 0.76 | GRM2 (0.62) | GRM2HTR2ASLC6A3CYP2C9CYP2C19 | |
| SCHEMBL19633041 | 0.74 | GRM2 (0.59) | GRM2SLC6A3CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL20842355 | 0.74 | GRM2 (0.50) | GRM2HTR2ASLC6A3CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459948-B1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-11-17 | — | — | EP | claimed |
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-07-04 | — | — | US | claimed |
| EP-3459948-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2019-03-27 | — | — | EP | claimed |
| EP-3459948-B1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-11-17 | — | — | EP | disclosed |
| EP-3459948-B1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-11-17 | — | — | EP | disclosed |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-10-13 | — | — | US | disclosed |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-10-13 | — | — | US | disclosed |
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-07-04 | — | — | US | disclosed |
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-07-04 | — | — | US | disclosed |
| EP-3459948-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2019-03-27 | — | — | EP | disclosed |
| EP-3459948-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017198180-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | GRM2, GRM1, GRIK2 | GRM2 1/4885HTR2A 69/4885SLC6A3 229/4885 |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | GRM2, GRM1, GRIK2 | GRM2 1/4885HTR2A 69/4885SLC6A3 229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.