Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.88 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.88 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183546 | 0.89 | CYP1A2 (0.76) | CYP1A2CYP2D6CYP2C19LMNATAAR1 | |
| SCHEMBL5275606 | 0.82 | CYP1A2 (0.66) | CYP1A2CYP2D6CYP2C19TAAR1CHRM2 | |
| SCHEMBL29672948 | 0.82 | CYP1A2 (0.65) | CYP1A2CYP2D6CYP2C19LMNATAAR1 | |
| SCHEMBL8583518 | 0.82 | CYP1A2 (0.65) | CYP1A2CYP2D6CYP2C19LMNATAAR1 | |
| SCHEMBL1420648 | 0.81 | CYP1A2 (0.62) | CYP1A2CYP2D6CYP2C19TAAR1SMN1; SMN2 | |
| SCHEMBL23682794 | 0.81 | CYP1A2 (0.64) | CYP1A2CYP2D6CYP2C19TAAR1CHRM2 | |
| SCHEMBL28274225 | 0.81 | CYP1A2 (0.59) | CYP1A2CYP2D6CYP2C19CHRM2HRH4 | |
| SCHEMBL11922793 | 0.81 | CYP1A2 (0.59) | CYP1A2CYP2D6CYP2C19CHRM2HRH4 | |
| SCHEMBL9257479 | 0.80 | CYP1A2 (0.76) | CYP1A2CYP2D6CYP2C19LMNACHRM2 | |
| SCHEMBL15859362 | 0.80 | CYP1A2 (0.76) | CYP1A2CYP2D6CYP2C19LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186808-A1 | NARGENICIN COMPOUNDS AND USES THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME LLC | 2018-07-05 | — | — | US | disclosed |
| WO-2017197488-A1 | LIBRARIES OF DIVERSE MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | CYCLENIUM PHARMA INC. (CA) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186808-A1 | NARGENICIN COMPOUNDS AND USES THEREOF AS ANTIBACTERIAL AGENTS | NRDC, MME, NME2 | CYP1A2 1840/4885CYP2D6 934/4885CYP2C19 2032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.