Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 11/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 10/20 | 0.51 |
| ▸ | RXRA | P19793 | 6/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455594 | 0.84 | NR1H2 (0.56) | NR1H3NR1H2RXRACARM1USP2 | |
| SCHEMBL16455253 | 0.83 | NR1H2 (0.54) | NR1H3NR1H2RXRACARM1CA1 | |
| SCHEMBL16455597 | 0.80 | NR1H2 (0.50) | NR1H3NR1H2RXRACARM1CA9 | |
| SCHEMBL16455598 | 0.79 | NR1H2 (0.48) | NR1H3NR1H2RXRACARM1CA9 | |
| SCHEMBL20726071 | 0.77 | NR1H2 (0.60) | NR1H3NR1H2RXRA | |
| SCHEMBL16455637 | 0.75 | NR1H2 (0.46) | NR1H3NR1H2RXRACARM1USP2 | |
| SCHEMBL16455384 | 0.75 | NR1H2 (0.46) | NR1H3NR1H2RXRAUSP2SMN1; SMN2 | |
| SCHEMBL16455255 | 0.74 | NR1H2 (0.48) | NR1H3NR1H2RXRACA1CA2 | |
| SCHEMBL16455652 | 0.74 | NR1H2 (0.48) | NR1H3NR1H2RXRACA1CA2 | |
| SCHEMBL19633310 | 0.72 | NR1H3 (0.50) | NR1H3NR1H2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334897-A1 | Liver X Receptor (LXR) Modulators For The Treatment Of Dermal Diseases, Disorders And Conditions | ALEXAR THERAPEUTICS, INC. | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334897-A1 | Liver X Receptor (LXR) Modulators For The Treatment Of Dermal Diseases, Disorders And Conditions | NR1H2, NR1H3, RXRA | NR1H3 2/4885NR1H2 1/4885RXRA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.