Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 9/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | YES1 | P07947 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16659621 | 0.93 | FGFR4 (0.37) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL30745811 | 0.93 | FGFR4 (0.37) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL19633240 | 0.91 | FGFR1 (0.33) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL18138247 | 0.87 | FGFR4 (0.35) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL23889743 | 0.86 | FGFR4 (0.37) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL23665610 | 0.84 | FGFR4 (0.38) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL17728857 | 0.80 | FGFR4 (0.43) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL20836819 | 0.80 | FGFR4 (0.39) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL28609741 | 0.79 | FGFR1 (0.33) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL18138353 | 0.79 | FGFR4 (0.34) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459952-A1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017198221-A1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | 浙江海正药业股份有限公司 | 2017-11-23 | — | — | WO | disclosed |