⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13112238 | 0.75 | KDM4E (0.47) | — | |
| SCHEMBL798445 | 0.75 | ALDH1A1 (0.33) | — | |
| SCHEMBL20853027 | 0.73 | — | — | |
| SCHEMBL13086732 | 0.72 | — | — | |
| SCHEMBL15935339 | 0.72 | KDM4E (0.35) | — | |
| SCHEMBL22607386 | 0.71 | ALDH1A1 (0.30) | — | |
| SCHEMBL19619534 | 0.71 | — | — | |
| SCHEMBL18237470 | 0.67 | — | — | |
| SCHEMBL22800214 | 0.64 | — | — | |
| SCHEMBL21566714 | 0.63 | NPSR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-11-23 | — | — | US | disclosed |