Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 7/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.64 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.64 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17495341 | 0.90 | TP53 (0.68) | GAKRIPK2COQ8ANLKTP53 | |
| SCHEMBL19633676 | 0.83 | GAK (0.68) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL30420525 | 0.82 | HTT (0.70) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL25466706 | 0.82 | GAK (0.67) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL21121632 | 0.82 | MAPT (0.69) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL25466634 | 0.81 | GAK (0.70) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL2205672 | 0.81 | GAK (0.65) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL30420470 | 0.79 | GAK (0.67) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL21121509 | 0.79 | HTT (0.64) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL21121679 | 0.79 | HTT (0.64) | GAKRIPK2COQ8ANLKHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198196-A1 | QUINOLINE DERIVATIVE HAVING ANTI-TUMOR ACTIVITY | 王子厚 | 2017-11-23 | — | — | WO | disclosed |