Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 9/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 8/20 | 0.64 |
| ▸ | COQ8A | Q8NI60 | 7/20 | 0.64 |
| ▸ | NLK | Q9UBE8 | 7/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | TERT | O14746 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633637 | 0.90 | GAK (0.64) | TP53SMN1; SMN2GAKRIPK2COQ8A | |
| SCHEMBL6088873 | 0.82 | SMN1; SMN2 (0.80) | TP53SMN1; SMN2HTTSLC2A1POLB | |
| SCHEMBL28864119 | 0.82 | GAK (0.64) | GAKRIPK2COQ8ANLKHTT | |
| SCHEMBL6091005 | 0.80 | SMN1; SMN2 (0.76) | TP53SMN1; SMN2SLC2A1POLBRAD52 | |
| SCHEMBL4380336 | 0.80 | MAPT (0.76) | TP53SMN1; SMN2KDREGFRLCK | |
| SCHEMBL28242716 | 0.78 | GAK (0.61) | GAKRIPK2COQ8ANLKHTT | |
| SCHEMBL6234851 | 0.77 | SMN1; SMN2 (0.71) | TP53SMN1; SMN2HTTEGFRSLC2A1 | |
| SCHEMBL282245 | 0.76 | LMNA (0.58) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL29729443 | 0.76 | LMNA (0.58) | GAKRIPK2COQ8ANLKHTR1A | |
| SCHEMBL3064565 | 0.75 | HTR1A (0.67) | GAKRIPK2COQ8ANLKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180140694-A1 | DOSAGE REGIMEN FOR HIV VACCINE | BIONOR IMMUNO AS (NO) | 2018-05-24 | — | — | US | claimed |
| WO-2016177833-A1 | DOSAGE REGIMEN FOR HIV VACCINE | BIONOR IMMUNO AS (NO) | 2016-11-10 | — | — | WO | claimed |
| US-20200163924-A1 | COMPOSITIONS AND METHODS FOR REACTIVATING LATENT VIRAL INFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-05-28 | — | — | US | disclosed |
| US-10376486-B2 | Compositions and methods for reactivating latent viral infections | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-08-13 | — | — | US | disclosed |
| US-20180140694-A1 | DOSAGE REGIMEN FOR HIV VACCINE | BIONOR IMMUNO AS (NO) | 2018-05-24 | — | — | US | disclosed |
| US-20170258750-A1 | COMPOSITIONS AND METHODS FOR REACTIVATING LATENT VIRAL INFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-09-14 | — | — | US | disclosed |
| WO-2016177833-A1 | DOSAGE REGIMEN FOR HIV VACCINE | BIONOR IMMUNO AS (NO) | 2016-11-10 | — | — | WO | disclosed |
| WO-2016022358-A1 | COMPOSITIONS AND METHODS FOR REACTIVATING LATENT VIRAL INFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10376486-B2 | Compositions and methods for reactivating latent viral infections | TRIM25, EBNA1BP2, TRIM33 | TP53 719/4885SMN1; SMN2 4408/4885GAK 1794/4885 |
| US-20170258750-A1 | COMPOSITIONS AND METHODS FOR REACTIVATING LATENT VIRAL INFECTIONS | TRIM25, EBNA1BP2, TRIM33 | TP53 719/4885SMN1; SMN2 4408/4885GAK 1794/4885 |
| US-20200163924-A1 | COMPOSITIONS AND METHODS FOR REACTIVATING LATENT VIRAL INFECTIONS | TRIM25, EBNA1BP2, TRIM33 | TP53 719/4885SMN1; SMN2 4408/4885GAK 1794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.