⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935310 | 0.82 | MEN1 (0.33) | — | |
| SCHEMBL19171548 | 0.72 | POLB (0.33) | — | |
| SCHEMBL19382091 | 0.70 | — | — | |
| SCHEMBL16417636 | 0.69 | — | — | |
| SCHEMBL19633600 | 0.68 | — | — | |
| SCHEMBL24983651 | 0.65 | LMNA (0.30) | — | |
| SCHEMBL19287712 | 0.64 | — | — | |
| SCHEMBL16677127 | 0.61 | HSP90AA1 (0.32) | — | |
| SCHEMBL12523344 | 0.61 | CYP19A1 (0.47) | — | |
| SCHEMBL22918490 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-11-23 | — | — | US | disclosed |