Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870877 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 | |
| SCHEMBL12698542 | 0.87 | HTT (0.48) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 | |
| SCHEMBL24774071 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL24252193 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 | |
| SCHEMBL25490941 | 0.83 | HTT (0.49) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL26272869 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 | |
| SCHEMBL23054326 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 | |
| SCHEMBL18499692 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 | |
| SCHEMBL15382668 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 | |
| SCHEMBL24279731 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AHTTTPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201442-A1 | ANTI-DLL3 DRUG CONJUGATES FOR TREATING TUMORS AT RISK OF NEUROENDOCRINE TRANSITION | ABBVIE STEMCENTRX LLC (US) | 2017-11-23 | — | — | WO | disclosed |