Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Px-102. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 known ✓ | Q96RI1 | 20/20 | 1.00 |
| ▸ | FXR2 | P51116 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Px-102 SCHEMBL1164533 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL29823470 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087856 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087855 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL29366746 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087854 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL24662891 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL17087850 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL29709582 | 1.00 | NR1H4 (1.00) | NR1H4FXR2 | |
| Px-102 SCHEMBL12098287 | 0.95 | NR1H4 (0.91) | NR1H4FXR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334893-A1 | Isoxazole Analogs as FXR Agonists and Methods of Use Thereof | ENANTA PHARMACEUTICALS, INC. | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334893-A1 | Isoxazole Analogs as FXR Agonists and Methods of Use Thereof | FXR1, SLC10A1, NR1H4 | NR1H4 3/4885FXR2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.