Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 12/20 | 0.37 |
| ▸ | SCN1A | P35498 | 9/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19631580 | 1.00 | SCN8A (0.37) | SCN8ASCN1ASCN5ANR1I2SCN1B | |
| SCHEMBL29447368 | 1.00 | SCN8A (0.37) | SCN8ASCN1ASCN5ANR1I2SCN1B | |
| SCHEMBL19627769 | 0.94 | SCN8A (0.37) | SCN8ASCN1ASCN5ANR1I2SCN1B | |
| SCHEMBL21118001 | 0.93 | RORC (0.36) | SCN8ASCN1ARORCSTSMAPT | |
| SCHEMBL19613495 | 0.92 | SCN8A (0.39) | SCN8ASCN1ASCN5ANR1I2SCN1B | |
| SCHEMBL29447359 | 0.86 | SCN8A (0.45) | SCN8ASCN1A | |
| SCHEMBL21117663 | 0.86 | SCN8A (0.45) | SCN8ASCN1A | |
| SCHEMBL19631748 | 0.86 | SCN8A (0.45) | SCN8ASCN1A | |
| SCHEMBL19634255 | 0.86 | SCN8A (0.45) | SCN8ASCN1A | |
| SCHEMBL19627770 | 0.81 | SCN8A (0.44) | SCN8ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | disclosed |