Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 2/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16078954 | 0.81 | KDM4C (0.66) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL16033464 | 0.78 | KDM5A (0.66) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL16078958 | 0.77 | KDM5B (0.52) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL17710641 | 0.77 | KDM5B (0.43) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL20979019 | 0.75 | KDM5B (0.45) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL16078929 | 0.72 | KDM4C (0.58) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL16078957 | 0.71 | KDM4C (0.69) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL20942774 | 0.71 | KDM4C (0.52) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL16078951 | 0.70 | KDM4C (0.70) | KDM4CKDM5BKDM2BKDM5AKDM4A | |
| SCHEMBL16078949 | 0.70 | KDM4C (0.71) | KDM4CKDM5BKDM2BKDM5AKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273222-B2 | Histone demethylase inhibitors | CELGENE QUANTSCEL RESEARCH, INC. (US) | 2019-04-30 | — | — | US | disclosed |
| US-20170334879-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273222-B2 | Histone demethylase inhibitors | KDM1B, KDM1A, KDM3B | KDM4C 13/4885KDM5B 10/4885KDM2B 19/4885 |
| US-20170334879-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, KDM3B | KDM4C 13/4885KDM5B 10/4885KDM2B 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.