Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.45 |
| ▸ | KDM5A | P29375 | 5/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.42 |
| ▸ | KDM4A | O75164 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20978948 | 0.90 | KDM5A (0.52) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL20979046 | 0.89 | KDM5B (0.48) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL20978701 | 0.89 | KDM4C (0.52) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL20979004 | 0.85 | KDM2B (0.49) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL16033464 | 0.84 | KDM5A (0.66) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL16078958 | 0.83 | KDM5B (0.52) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL16078954 | 0.80 | KDM4C (0.66) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL17710641 | 0.77 | KDM5B (0.43) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL19634666 | 0.75 | KDM4C (0.43) | KDM5BKDM5AKDM2BKDM4CKDM4A | |
| SCHEMBL16078929 | 0.75 | KDM4C (0.58) | KDM5BKDM5AKDM2BKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2019-05-08 | — | — | EP | disclosed |