Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.56 |
| ▸ | LCK | P06239 | 4/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.55 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | ITK | Q08881 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28370688 | 1.00 | BTK (0.56) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635195 | 1.00 | BTK (0.56) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635199 | 0.92 | BTK (0.67) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL28370698 | 0.92 | BTK (0.67) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635197 | 0.92 | BTK (0.67) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635213 | 0.92 | BTK (0.55) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635652 | 0.92 | BTK (0.55) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635214 | 0.92 | BTK (0.55) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635788 | 0.85 | BTK (0.68) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635217 | 0.85 | BTK (0.68) | BTKLCKLYNNUDT14NUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111153906-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111153906-A | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-107383013-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-03-31 | — | — | CN | disclosed |
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |