Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.68 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | BMX | P51813 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | HCK | P08631 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.49 |
| ▸ | PRKDC | P78527 | 2/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.48 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635788 | 1.00 | BTK (0.68) | BTKEGFRSRCBMXNR4A3 | |
| SCHEMBL19635218 | 1.00 | BTK (0.68) | BTKEGFRSRCBMXNR4A3 | |
| SCHEMBL28370698 | 0.85 | BTK (0.67) | BTKEGFRSRCKDRLCK | |
| SCHEMBL19635197 | 0.85 | BTK (0.67) | BTKEGFRSRCKDRLCK | |
| SCHEMBL19635199 | 0.85 | BTK (0.67) | BTKEGFRSRCKDRLCK | |
| SCHEMBL19635808 | 0.85 | BTK (0.67) | BTKEGFRSRCBMXNR4A3 | |
| SCHEMBL19635807 | 0.85 | BTK (0.67) | BTKEGFRSRCBMXNR4A3 | |
| SCHEMBL19635195 | 0.85 | BTK (0.56) | BTKEGFRSRCKDRLCK | |
| SCHEMBL28370688 | 0.85 | BTK (0.56) | BTKEGFRSRCKDRLCK | |
| SCHEMBL19635196 | 0.85 | BTK (0.56) | BTKEGFRSRCKDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111153906-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111153906-A | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-107383013-B | Pyrazolopyrimidine derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-03-31 | — | — | CN | disclosed |
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |