Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.66 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.66 |
| ▸ | BAD | Q92934 | 3/20 | 0.66 |
| ▸ | BCL2 | P10415 | 2/20 | 0.66 |
| ▸ | PMAIP1 | Q13794 | 6/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635905 | 0.92 | MCL1 (0.70) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL24722589 | 0.91 | BAD (0.80) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL19615167 | 0.88 | MCL1 (0.83) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL19635903 | 0.88 | MCL1 (0.62) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL24378233 | 0.88 | BAD (0.56) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL19615277 | 0.87 | MCL1 (0.72) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL19615374 | 0.86 | MCL1 (0.65) | MCL1BCL2L1BADBCL2PMAIP1 | |
| Diethylamine SCHEMBL19615101 | 0.85 | MCL1 (0.78) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL23786354 | 0.85 | BAD (0.82) | MCL1BCL2L1BADBCL2PMAIP1 | |
| SCHEMBL24378137 | 0.85 | MCL1 (0.58) | MCL1BCL2L1BADBCL2PMAIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |