Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 18/20 | 0.62 |
| ▸ | PMAIP1 | Q13794 | 12/20 | 0.61 |
| ▸ | BAD | Q92934 | 5/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.56 |
| ▸ | BCL2 | P10415 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24722555 | 0.89 | MCL1 (0.67) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL19635481 | 0.88 | MCL1 (0.66) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL19615054 | 0.88 | MCL1 (0.80) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL19635902 | 0.86 | MCL1 (0.69) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL19635399 | 0.85 | MCL1 (0.60) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23786314 | 0.83 | MCL1 (0.69) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL24378113 | 0.82 | MCL1 (0.46) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL19615128 | 0.81 | MCL1 (0.72) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL19635588 | 0.80 | MCL1 (0.61) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL19635737 | 0.80 | MCL1 (0.82) | MCL1PMAIP1BADBCL2L1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |