Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | ITK | Q08881 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 16/20 | 0.50 |
| ▸ | BLK | P51451 | 2/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CSK | P41240 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635795 | 0.80 | JAK3 (0.61) | JAK3JAK2ITKBTKJAK1 | |
| SCHEMBL19635789 | 0.79 | BTK (0.68) | JAK3JAK2ITKBTKBLK | |
| SCHEMBL19636020 | 0.79 | BTK (0.68) | JAK3JAK2ITKBTKBLK | |
| SCHEMBL19635812 | 0.78 | JAK3 (0.60) | JAK3JAK2ITKBTK | |
| SCHEMBL19635803 | 0.78 | JAK2 (0.64) | JAK3JAK2ITKBTKJAK1 | |
| SCHEMBL17479775 | 0.77 | BTK (0.74) | JAK3ITKBTKBLKFGR | |
| SCHEMBL19636023 | 0.77 | JAK2 (0.64) | JAK3JAK2ITKBTK | |
| SCHEMBL19635797 | 0.77 | JAK2 (0.64) | JAK3JAK2ITKBTK | |
| SCHEMBL19635793 | 0.74 | BTK (0.61) | JAK3JAK2ITKBTKBLK | |
| SCHEMBL19635799 | 0.74 | BTK (0.61) | JAK3JAK2ITKBTKBLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |