Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.64 |
| ▸ | ITK | Q08881 | 6/20 | 0.58 |
| ▸ | EGFR | P00533 | 8/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | PRKDC | P78527 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | HCK | P08631 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635794 | 0.78 | JAK3 (0.61) | JAK2JAK3ITKJAK1BTK | |
| SCHEMBL17479775 | 0.78 | BTK (0.74) | JAK3ITKEGFRABL1HCK | |
| SCHEMBL28399202 | 0.77 | JAK2 (0.65) | JAK2JAK3ITKEGFRJAK1 | |
| SCHEMBL28399199 | 0.77 | JAK2 (0.65) | JAK2JAK3ITKEGFRJAK1 | |
| SCHEMBL19635797 | 0.77 | JAK2 (0.64) | JAK2JAK3ITKEGFRSRC | |
| SCHEMBL19636023 | 0.77 | JAK2 (0.64) | JAK2JAK3ITKEGFRSRC | |
| SCHEMBL19635812 | 0.75 | JAK3 (0.60) | JAK2JAK3ITKEGFRBTK | |
| SCHEMBL19635795 | 0.75 | JAK3 (0.61) | JAK2JAK3ITKEGFRJAK1 | |
| SCHEMBL19635789 | 0.75 | BTK (0.68) | JAK2JAK3ITKEGFRSRC | |
| SCHEMBL19636020 | 0.75 | BTK (0.68) | JAK2JAK3ITKEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |