Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.47 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | IL1B | P01584 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382787 | 0.91 | CRBN (0.59) | CRBNCSNK1A1IKZF1TSHRMAPK10 | |
| SCHEMBL1962654 | 0.87 | CRBN (0.59) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL1961984 | 0.87 | CRBN (0.59) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL1961875 | 0.87 | CRBN (0.59) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL1962178 | 0.87 | CRBN (0.59) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL5136917 | 0.86 | CRBN (0.65) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL1962021 | 0.86 | CRBN (0.60) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL502015 | 0.85 | CRBN (0.64) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL1964285 | 0.85 | CRBN (0.64) | CRBNCSNK1A1IKZF1BRD4TNF | |
| SCHEMBL1962474 | 0.85 | CRBN (0.57) | CRBNCSNK1A1IKZF1BRD4TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SEPRACOR INC. | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SI, CYP3A5, CYP2D6 | CRBN 2589/4885CSNK1A1 137/4885IKZF1 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.