SCHEMBL19635979

SCHEMBL19635979

CC(C)(C)OC(=O)N/N=C1\CCC2(CC2)N(C(=O)OCc2ccccc2)C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.39
KMT2A Q03164 2/20 0.39
ALDH1A1 P00352 1/20 0.39
NPFFR1 Q9GZQ6 1/20 0.38
NPFFR2 Q9Y5X5 1/20 0.38
CTSL P07711 1/20 0.38
PDE4B Q07343 1/20 0.37
IDO1 P14902 1/20 0.36
TSHR P16473 1/20 0.36
CYP1A2 P05177 1/20 0.36
PPARA Q07869 1/20 0.35
SIGMAR1 Q99720 2/20 0.35
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA7 P43166 1/20 0.35
CA14 Q9ULX7 1/20 0.35
HTR2C P28335 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17157090 0.81 TMEM97 (0.48) KMT2ACTSLPDE4BSIGMAR1NPC1
SCHEMBL16075640 0.81 TMEM97 (0.48) KMT2ACTSLPDE4BSIGMAR1NPC1
SCHEMBL20836083 0.81 ALDH1A1 (0.45) KMT2AALDH1A1NPFFR1NPFFR2NPC1
SCHEMBL11981643 0.79 ALDH1A1 (0.49) SYKKMT2AALDH1A1CTSLSIGMAR1
SCHEMBL15670663 0.78 ALDH1A1 (0.46) SYKKMT2AALDH1A1CTSLPDE4B
SCHEMBL15670661 0.78 ALDH1A1 (0.46) SYKKMT2AALDH1A1CTSLPDE4B
SCHEMBL19635977 0.74 PDE4B (0.43) SYKKMT2AALDH1A1CTSLPDE4B
SCHEMBL19635980 0.74 NPC1 (0.50) KMT2AALDH1A1NPC1RAB9AL3MBTL1
SCHEMBL15653564 0.72 ALDH1A1 (0.54) SYKKMT2AALDH1A1CTSLTSHR
SCHEMBL24403426 0.71 NPFFR1 (0.48) KMT2AALDH1A1NPFFR1NPFFR2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3708165-B1 CRYSTAL FORM I OF A 5-AMINOPYRAZOLE CARBOXAMIDE COMPOUND AS BTK INHIBITOR SINOMAB BIOSCIENCE LTD (CN) 2023-01-18 EP disclosed
EP-3459940-B1 5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF SUZHOU SINOVENT PHARMACEUTICALS CO LTD (CN) 2022-07-20 EP disclosed
WO-2017198050-A1 5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF 浙江予川医药科技有限公司 2017-11-23 WO disclosed