Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GRN | P28799 | 3/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18513046 | 0.77 | KDM4E (0.38) | KDM4EPOLBCDK8AURKACSF1R | |
| SCHEMBL821308 | 0.74 | KDM4E (0.52) | KDM4EGRNSORT1MAPK14MAPK13 | |
| SCHEMBL10156873 | 0.73 | GRN (0.37) | KDM4EGRNSORT1POLBCDK8 | |
| SCHEMBL31688301 | 0.71 | KDM4E (0.36) | KDM4EGRNSORT1POLB | |
| SCHEMBL15069896 | 0.70 | GRN (0.35) | KDM4EGRNSORT1POLBMAPK14 | |
| SCHEMBL7249740 | 0.70 | GRN (0.35) | KDM4EGRNSORT1POLB | |
| SCHEMBL15069883 | 0.70 | GRN (0.38) | KDM4EGRNSORT1ALDH1A1 | |
| SCHEMBL18496476 | 0.67 | MAPK14 (0.50) | GRNSORT1CDK8ALDH1A1MAPK14 | |
| SCHEMBL716572 | 0.67 | KDM4E (0.33) | KDM4EGRNSORT1MAPK14MAPK13 | |
| SCHEMBL2060008 | 0.67 | GRN (0.49) | KDM4EGRNSORT1CDK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334835-A1 | Non-Lactone Carbocyclic and Heterocyclic Antagonists and Agonists of Bacterial Quorum Sensing | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334835-A1 | Non-Lactone Carbocyclic and Heterocyclic Antagonists and Agonists of Bacterial Quorum Sensing | CCKAR, PAM, CNR1 | KDM4E 2939/4885GRN 2763/4885SORT1 4447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.