PAM

Peptidyl-glycine alpha-amidating monooxygenase · P19021 · PAM on Sugi Atlas →

44,953 patent compounds predicted against PAM, 30,534 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL126976 SCHEMBL126976 0.69 3/20
SCHEMBL94604 SCHEMBL94604 0.60 3/20
SCHEMBL179684 SCHEMBL179684 0.52 3/20
SCHEMBL162936 SCHEMBL162936 0.50 3/20
SCHEMBL75506 SCHEMBL75506 0.38 3/20
SCHEMBL156767 SCHEMBL156767 1.00 2/20
SCHEMBL454 SCHEMBL454 0.67 2/20
SCHEMBL1585 SCHEMBL1585 0.67 2/20
SCHEMBL5533 SCHEMBL5533 0.67 2/20
SCHEMBL8538 SCHEMBL8538 0.67 2/20
SCHEMBL24287 SCHEMBL24287 0.67 2/20
SCHEMBL25276 SCHEMBL25276 0.67 2/20
Glycol Distearate Glycol Distearate (SCHEMBL29407) 0.67 2/20
SCHEMBL102577 SCHEMBL102577 0.67 2/20
Ethyl Tetradecanoate Ethyl Tetradecanoate (SCHEMBL116495) 0.67 2/20
SCHEMBL116995 SCHEMBL116995 0.67 2/20
SCHEMBL120620 SCHEMBL120620 0.67 2/20
SCHEMBL137195 SCHEMBL137195 0.67 2/20
SCHEMBL16463 SCHEMBL16463 0.66 2/20
Acetic Acid Acetic Acid (SCHEMBL87739) 0.66 2/20

Clinical trials — most relevant to PAM by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing PHASE4COMPLETED
A Study to Assess the Efficacy and Safety of the Triptorelin 6-month Formulation in Paediatric Participants With Central Precocious Puberty. PHASE3COMPLETED
Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Chinese Subjects With Endometriosis PHASE3COMPLETED
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH) PHASE3COMPLETED
Pasireotide in Patients With Acromegaly Inadequately Controlled With First Generation Somatostatin Analogues PHASE3COMPLETED
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Triptorelin for Ovary Protection in Childhood Onset Lupus PHASE2COMPLETED
Study of ARO-DIMERPA in Adult Participants With Mixed Hyperlipidemia PHASE1/PHASE2RECRUITING
A Study to Evaluate the Safety, Tolerability and Efficacy in Patients With Burn(s) PHASE1/PHASE2NOT_YET_RECRUITING
Pasireotide LAR Administration in Lymphocele Prevention After Axillary Node Dissection for Breast Cancer PHASE2COMPLETED
Reduction by Pasireotide of the Effluent Volume in High-output Enterostomy in Patients Refractory to Usual Medical Treatment PHASE2COMPLETED
Pamiparib for Consolidation Treatment of Unprogressed LS-SCLC After Concurrent Chemoradiotherapy PHASE2UNKNOWN
Dose-Finding Study to Evaluate the Safety, Efficacy, & Tolerability of Multiple Doses of rAvPAL-PEG in Subjects With PKU PHASE2COMPLETED
Efficacy Study of Pegylated Recombinant Human Arginase 1 as a Second-line Therapy in Patients With Advanced Liver Cancer PHASE2COMPLETED
Glembatumumab Vedotin in Treating Patients With Metastatic or Locally Recurrent Uveal Melanoma PHASE2COMPLETED
The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine PHASE1WITHDRAWN
A Study of [11C]JNJ-42491293, a Possible PET Ligand for the mGlu2 Receptor, in Healthy Adult Volunteers PHASE1COMPLETED
Sorafenib Study: Dosing in Patients With Pulmonary Arterial Hypertension (PAH) PHASE1COMPLETED
Study of Pasireotide Long Acting Release (LAR) Injection in Patients With Acromegaly and Patients With Carcinoid Disease PHASE1COMPLETED
Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-Pamiparib in Participants With Advanced Cancer PHASE1COMPLETED
Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects PHASE1COMPLETED
Study of Avatrombopag for Temozolomide-induced Thrombocytopenia in Glioma (APATIT-G) EARLY_PHASE1WITHDRAWN
Accuracy of Detection of Methemoglobin With Pulse Oximetry nanCOMPLETED
Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19) nanRECRUITING
The Protrieve PROTECTOR Study nanCOMPLETED
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load nanCOMPLETED
The Recovery in Stroke Using PAP Study nanRECRUITING
Avatrombopag for Platelet Recovery Post-UCBT in Patients With Bone Marrow Failure Disease nanRECRUITING
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions nanRECRUITING
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PAM binder may also engage these)

ProteinNameSimilarity
P10731 1.000 P10731 →
P97467 1.000 P97467 →
P08478 0.999 P08478 →
P14925 0.998 P14925 →
O18016 0.996 O18016 →
Q28056 0.995 Q28056 →
P12890 0.994 P12890 →
P34822 0.993 P34822 →
O35312 0.993 O35312 →
Q9XTQ6 0.992 Q9XTQ6 →
Q94128 0.992 Q94128 →
O54861 0.992 O54861 →
O95393 0.991 O95393 →
Q8BSY0 0.991 Q8BSY0 →
Q6UX71 0.991 Q6UX71 →
Q8UWD9 0.991 Q8UWD9 →
P52194 0.991 P52194 →
E1C3U7 0.991 E1C3U7 →
A6H737 0.991 A6H737 →
SORT1 Sortilin 0.991 landscape →
Q98TB4 0.991 Q98TB4 →
P84903 0.991 P84903 →
Q5QQ55 0.990 Q5QQ55 →
Q8AXC7 0.990 Q8AXC7 →
STIM1 Stromal interaction molecule 1 0.990 landscape →
Q09499 0.990 Q09499 →
Q9WTR0 0.990 Q9WTR0 →
O42222 0.990 O42222 →
O64758 0.990 O64758 →
B3NBB6 0.989 B3NBB6 →