Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.38 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1961729 | 0.99 | CRBN (0.51) | CRBNDDB1CSNK1A1IKZF1AXL | |
| SCHEMBL1962931 | 0.87 | CRBN (0.53) | CRBNDDB1CSNK1A1IKZF1AXL | |
| SCHEMBL1964489 | 0.87 | CRBN (0.55) | CRBNDDB1CSNK1A1IKZF1BRD4 | |
| SCHEMBL1964606 | 0.87 | CRBN (0.55) | CRBNDDB1CSNK1A1IKZF1AXL | |
| SCHEMBL1963968 | 0.86 | CRBN (0.52) | CRBNDDB1CSNK1A1IKZF1AXL | |
| SCHEMBL1962646 | 0.86 | CRBN (0.54) | CRBNDDB1CSNK1A1IKZF1AXL | |
| Hydrochloric Acid SCHEMBL1963613 | 0.85 | CRBN (0.53) | CRBNDDB1CSNK1A1IKZF1AXL | |
| SCHEMBL1963480 | 0.85 | CRBN (0.60) | CRBNDDB1CSNK1A1IKZF1BRD4 | |
| SCHEMBL1963070 | 0.85 | CRBN (0.55) | CRBNDDB1CSNK1A1IKZF1IKZF3 | |
| SCHEMBL1961484 | 0.84 | CRBN (0.51) | CRBNDDB1CSNK1A1IKZF1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919892-B1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8481568-B2 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SEPRACOR INC. | 2011-06-16 | — | — | US | disclosed |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SI, CYP3A5, CYP2D6 | CRBN 2589/4885DDB1 4509/4885CSNK1A1 137/4885 |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | SI, CYP3A5, CYP2D6 | CRBN 2589/4885DDB1 4509/4885CSNK1A1 137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.