Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 6/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR1F | P30939 | 1/20 | 0.31 |
| ▸ | HRAS | P01112 | 4/20 | 0.31 |
| ▸ | ESR1 | P03372 | 4/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.31 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19637500 | 0.87 | ERBB2 (0.43) | ERBB2FGFR1FGFR4HDAC1HDAC2 | |
| SCHEMBL19614875 | 0.85 | FGFR1 (0.39) | ERBB2FGFR1FGFR4AGPAT2HTR1A | |
| SCHEMBL19633096 | 0.84 | FGFR1 (0.37) | ERBB2FGFR1FGFR4AGPAT2HDAC8 | |
| SCHEMBL19633090 | 0.84 | ERBB2 (0.41) | ERBB2AGPAT2HRASESR1ESR2 | |
| Hydrochloric Acid SCHEMBL30464341 | 0.83 | ERBB2 (0.39) | ERBB2AGPAT2HRASESR1ESR2 | |
| Hydrochloric Acid SCHEMBL19614885 | 0.83 | ERBB2 (0.39) | ERBB2AGPAT2HRASESR1ESR2 | |
| Hydrochloric Acid SCHEMBL30464359 | 0.83 | ERBB2 (0.41) | ERBB2AGPAT2HRASESR1ESR2 | |
| SCHEMBL19633039 | 0.82 | ERBB2 (0.40) | ERBB2AGPAT2HRASESR1ESR2 | |
| Hydrochloric Acid SCHEMBL30464360 | 0.81 | ERBB2 (0.40) | ERBB2AGPAT2HRASESR1ESR2 | |
| SCHEMBL19636936 | 0.81 | ERBB2 (0.40) | ERBB2AGPAT2HRASESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10660901-B2 | Pyrrolobenzodiazepines and conjugates thereof | MERSANA THERAPEUTICS, INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190070194-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. | 2019-03-07 | — | — | US | disclosed |
| US-20170333442-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333442-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD79B, CLTB, FCGR3B | ERBB2 65/4885FGFR1 1664/4885FGFR4 1022/4885 |
| US-20190070194-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD79B, CLTB, FCGR3B | ERBB2 65/4885FGFR1 1664/4885FGFR4 1022/4885 |
| US-10660901-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD79B, CLTB, FCGR3B | ERBB2 65/4885FGFR1 1664/4885FGFR4 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.