Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616489 | 0.93 | TMEM97 (0.46) | TMEM97SIGMAR1MTORTLR9TLR7 | |
| SCHEMBL22010705 | 0.90 | TMEM97 (0.45) | TMEM97SIGMAR1MTORTLR9TLR7 | |
| SCHEMBL30421626 | 0.89 | TLR9 (0.43) | TMEM97SIGMAR1MTORTLR9TLR7 | |
| SCHEMBL19616716 | 0.86 | TMEM97 (0.47) | TMEM97SIGMAR1MTORTLR9TLR7 | |
| SCHEMBL19617028 | 0.86 | GPR119 (0.45) | TMEM97SIGMAR1MTORTLR9TLR7 | |
| SCHEMBL20975106 | 0.84 | TMEM97 (0.45) | TMEM97SIGMAR1MTORTLR9TLR7 | |
| SCHEMBL22479711 | 0.84 | MTOR (0.42) | TMEM97SIGMAR1MTORTLR9TLR7 | |
| SCHEMBL21315070 | 0.84 | TMEM97 (0.45) | TMEM97SIGMAR1MTORMEN1KMT2A | |
| SCHEMBL19617024 | 0.83 | TMEM97 (0.51) | TMEM97SIGMAR1TLR9TLR7ACHE | |
| SCHEMBL19616526 | 0.81 | TMEM97 (0.43) | TMEM97SIGMAR1MEN1KMT2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |