Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 11/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 11/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323231 | 0.80 | NPC1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL976208 | 0.76 | NPC1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL7341928 | 0.74 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL977504 | 0.74 | NPC1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL8301061 | 0.72 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL7342934 | 0.72 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL7334470 | 0.72 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL7341752 | 0.71 | AGTR1 (0.40) | AGTR1AGTR2CYP11B1CYP11B2 | |
| SCHEMBL8841908 | 0.71 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL8841436 | 0.71 | AGTR1 (0.61) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334651-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |