Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | GMNN | O75496 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.74 |
| ▸ | THPO | P40225 | 1/20 | 0.74 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.74 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658529 | 0.93 | SMN1; SMN2 (0.89) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL5318105 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL4308 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL23753952 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL28426894 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL28081945 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL4176516 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL5846926 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL11252839 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 | |
| Chlorambucil SCHEMBL28447772 | 0.84 | SMN1; SMN2 (0.97) | SMN1; SMN2MAPTCYP2D6GMNNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311802-B | Chlorambucil formulations | 珠海贝海生物技术有限公司 | 2022-02-08 | — | — | CN | disclosed |
| US-20190142748-A1 | FORMULATIONS OF CHLORAMBUCIL | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2019-05-16 | — | — | US | disclosed |
| US-20190142748-A1 | FORMULATIONS OF CHLORAMBUCIL | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2019-05-16 | — | — | US | disclosed |
| WO-2017205588-A1 | FORMULATIONS OF CHLORAMBUCIL | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2017-11-30 | — | — | WO | disclosed |
| WO-2017205588-A1 | FORMULATIONS OF CHLORAMBUCIL | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2017-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190142748-A1 | FORMULATIONS OF CHLORAMBUCIL | ALB, SLCO4C1, BCL9L | SMN1; SMN2 2021/4885MAPT 993/4885CYP2D6 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.