Sugi Predict

Sugi Predict / Compounds / SCHEMBL19643736

SCHEMBL19643736

SCHEMBL19643736

CSc1ncc(C=CC(=O)O)c(=O)[nH]1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM6B O15054 6/20 0.56
▸ KDM4A O75164 6/20 0.56
▸ HIF1AN Q9NWT6 6/20 0.56
▸ KDM2A Q9Y2K7 6/20 0.56
▸ KDM4D Q6B0I6 5/20 0.56
▸ KDM3B Q7LBC6 5/20 0.47
▸ KDM5B Q9UGL1 5/20 0.47
▸ LMNA P02545 1/20 0.42
▸ NPC1 O15118 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ PARP1 P09874 1/20 0.35
▸ TBXA2R P21731 1/20 0.35
▸ PTGER3 P43115 1/20 0.35
▸ PTGER2 P43116 1/20 0.35
▸ PTGDR Q13258 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ BLM P54132 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19661703 1.00 KDM6B (0.56) KDM6BKDM4AHIF1ANKDM2AKDM4D
SCHEMBL23877685 1.00 KDM6B (0.56) KDM6BKDM4AHIF1ANKDM2AKDM4D
SCHEMBL4766387 0.72 KDM6B (1.00) KDM6BKDM4AHIF1ANKDM2AKDM4D
SCHEMBL13525026 0.70 KDM6B (0.61) KDM6BKDM4AHIF1ANKDM2AKDM4D
SCHEMBL9956612 0.69 KDM6B (0.75) KDM6BKDM4AHIF1ANKDM2AKDM4D
SCHEMBL4001347 0.69 KDM6B (0.59) KDM6BKDM4AHIF1ANKDM2AKDM4D
SCHEMBL3577936 0.68 KDM6B (0.58) KDM6BKDM4AHIF1ANKDM2AKDM4D
SCHEMBL23414166 0.67 MEN1 (0.42) LMNAALDH1A1TBXA2RPTGER3PTGER2
SCHEMBL4715171 0.67 MEN1 (0.42) LMNAALDH1A1TBXA2RPTGER3PTGER2
SCHEMBL19725083 0.66 KDM6B (0.56) KDM6BKDM4AHIF1ANKDM2AKDM4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220096485-A1 FUNCTIONALIZED PYRANO[2,3-D]PYRIMIDIN-7-ONE DERIVATIVES AND METHODS FOR THEIR PREPARATION AND USE THE TEXAS A&M UNIVERSITY SYSTEM (US) 2022-03-31 — — US disclosed
US-11136333-B2 Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use THE TEXAS A&M UNIVERSITY SYSTEM (US) 2021-10-05 — — US disclosed
WO-2017205432-A1 FUNCTIONALIZED PYRANO[2,3-D]PYRIMIDIN-7-ONE DERIVATIVES AND METHODS FOR THEIR PREPARATION AND USE LU DAI (US) 2017-11-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11136333-B2 Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use MAP3K7, MAP4K2, MAP3K8 KDM6B 1936/4885KDM4A 2607/4885HIF1AN 1095/4885
US-20220096485-A1 FUNCTIONALIZED PYRANO[2,3-D]PYRIMIDIN-7-ONE DERIVATIVES AND METHODS FOR THEIR PREPARATION AND USE MAP3K7, MAP4K2, MAP3K8 KDM6B 1936/4885KDM4A 2607/4885HIF1AN 1095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.