Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.56 |
| ▸ | KDM4A | O75164 | 1/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.56 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577936 | 0.78 | KDM6B (0.58) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL2713726 | 0.76 | KDM6B (0.56) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL13525026 | 0.76 | KDM6B (0.61) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL16466339 | 0.76 | KDM6B (0.56) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL2072718 | 0.76 | KDM6B (0.56) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL18689737 | 0.73 | KDM6B (0.53) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL11900387 | 0.73 | LMNA (0.59) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL23461193 | 0.72 | — | — | |
| SCHEMBL18337906 | 0.72 | L3MBTL1 (0.41) | LMNAL3MBTL1KMT2AALDH1A1MEN1 | |
| SCHEMBL2027355 | 0.72 | MAPK1 (0.69) | KDM6BKDM4AKDM4DHIF1ANKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438056-B1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS LLC (US) | 2017-12-20 | — | — | EP | disclosed |