Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20985757 | 0.97 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL20985770 | 0.93 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19643148 | 0.89 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19643100 | 0.89 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19643993 | 0.86 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19643196 | 0.86 | ROCK2 (0.85) | ROCK2 | |
| SCHEMBL19644097 | 0.85 | ROCK2 (0.84) | ROCK2 | |
| SCHEMBL19643606 | 0.85 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19643215 | 0.85 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL21025327 | 0.85 | ROCK2 (1.00) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464262-A1 | TRIAZOLONES AND TETRAZOLONES AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017205709-A1 | TRIAZOLONES AND TETRAZOLONES AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-11-30 | — | — | WO | disclosed |