Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GJB2 | P29033 | 5/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.41 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LGALS8 | O00214 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17359603 | 1.00 | GJB2 (0.52) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL12924474 | 1.00 | GJB2 (0.52) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL280278 | 1.00 | GJB2 (0.52) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL15948696 | 1.00 | GJB2 (0.52) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL17976782 | 1.00 | GJB2 (0.52) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL14532055 | 0.96 | GJB2 (0.48) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL14440515 | 0.94 | GJB2 (0.47) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL14440517 | 0.94 | GJB2 (0.47) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL12898674 | 0.93 | GJB2 (0.54) | GJB2TNFSSTR1SSTR2SSTR4 | |
| SCHEMBL14440521 | 0.92 | GJB2 (0.50) | GJB2TNFSSTR1SSTR2SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828388-B2 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2017-11-28 | — | — | US | disclosed |