GJB2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL971021	0.55	7/20
SCHEMBL971023	0.55	7/20
Tobramycin (SCHEMBL316999)	0.63	6/20
Tobramycin (SCHEMBL317114)	0.63	6/20
Tobramycin (SCHEMBL1177718)	0.63	6/20
Tobramycin (SCHEMBL2478754)	0.63	6/20
Tobramycin (SCHEMBL2526940)	0.63	6/20
Amikacin (SCHEMBL315999)	0.58	6/20
Amikacin (SCHEMBL316574)	0.58	6/20
Amikacin (SCHEMBL318027)	0.58	6/20
Amikacin (SCHEMBL2476777)	0.58	6/20
SCHEMBL411272	0.61	5/20
SCHEMBL411623	0.61	5/20
SCHEMBL2736469	0.61	5/20
SCHEMBL2736466	0.55	5/20
SCHEMBL2670685	0.54	5/20
SCHEMBL2670689	0.54	5/20
SCHEMBL280278	0.52	5/20
SCHEMBL412539	0.51	5/20
SCHEMBL672020	0.48	5/20

Clinical trials — most relevant to GJB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
StereoTactic Arrhythmia Radiotherapy in the NetherLands no. 2	PHASE2	RECRUITING
Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss	PHASE1/PHASE2	RECRUITING
The Synapse Project	PHASE2	COMPLETED
Prevention of Preterm Delivery in Twin Pregnancies by 17 Alpha-hydroxyprogesterone Caproate	PHASE2	COMPLETED
Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn	PHASE1	COMPLETED
Whole Heart Radiotherapy for End-stage Heart Failure	PHASE1	ENROLLING_BY_INVITATION
68Ga-PMD22 PET/CT Examination Targeting CLDN18.2	EARLY_PHASE1	UNKNOWN
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis	nan	RECRUITING
High Density Mapping in Brugada Syndrome	nan	COMPLETED
Typical and Atypical AVNRT High-resolution Mapping	nan	UNKNOWN
A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations	nan	WITHDRAWN
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome	nan	COMPLETED
Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes	nan	RECRUITING
Neuromuscular Transmission in Amyotrophic Lateral Sclerosis	nan	COMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Histological and Molecular Mechanisms of Pain in Patient With Chronic Pain From Adhesions	nan	COMPLETED
Variability of the Unique Fiber Potentials of a Spastic Muscle Treated With Botulinum Toxin	nan	COMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients	nan	NOT_YET_RECRUITING
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study	nan	COMPLETED
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
Evaluation of the Clinical Course of NERD and Assessment of the Esophageal Mucosa Resistance	nan	ACTIVE_NOT_RECRUITING
Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study	nan	UNKNOWN
Painful Channelopathies Study	nan	UNKNOWN
The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients	nan	COMPLETED
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals	nan	ENROLLING_BY_INVITATION
Multidisciplinary Study of Right Ventricular Dysplasia	nan	COMPLETED
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Topographic Changes of Retinal Layers After Resolution of Acute Retinal Detachment	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GJB2 binder may also engage these)

Protein	Name	Similarity
Q8MHW5	—	1.000	Q8MHW5 →
Q8MIT8	—	1.000	Q8MIT8 →
Q8MIT9	—	1.000	Q8MIT9 →
P21994	—	1.000	P21994 →
P46691	—	1.000	P46691 →
Q7JGL3	—	1.000	Q7JGL3 →
A2VE67	—	1.000	A2VE67 →
Q6PEY0	—	1.000	Q6PEY0 →
Q7T047	—	1.000	Q7T047 →
Q00977	—	0.999	Q00977 →
P36380	—	0.998	P36380 →
O93533	—	0.997	O93533 →
Q9CX92	—	0.996	Q9CX92 →
U3JA75	—	0.996	U3JA75 →
Q02739	—	0.995	Q02739 →
O95452	—	0.995	O95452 →
P28231	—	0.995	P28231 →
O18968	—	0.994	O18968 →
Q9NTQ9	—	0.994	Q9NTQ9 →
Q60HF7	—	0.993	Q60HF7 →
P69998	—	0.992	P69998 →
P70689	—	0.992	P70689 →
P08983	—	0.992	P08983 →
Q5E9Z5	—	0.992	Q5E9Z5 →
P28230	—	0.991	P28230 →
A6NN92	—	0.990	A6NN92 →
P25305	—	0.990	P25305 →
P08034	—	0.990	P08034 →
P08033	—	0.989	P08033 →
Q6WGK6	—	0.989	Q6WGK6 →