Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.54 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.37 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.34 |
| ▸ | RNASEL | Q05823 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | ENTPD1 | P49961 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17453492 | 1.00 | POLRMT (0.54) | POLRMTP2RY2P2RY1P2RY11IMPDH2 | |
| SCHEMBL17453490 | 1.00 | POLRMT (0.54) | POLRMTP2RY2P2RY1P2RY11IMPDH2 | |
| SCHEMBL21137369 | 0.91 | POLRMT (0.54) | POLRMTP2RY2P2RY1P2RY11P2RX3 | |
| SCHEMBL19644660 | 0.91 | POLRMT (0.54) | POLRMTP2RY2P2RY1P2RY11P2RX3 | |
| SCHEMBL17465450 | 0.91 | POLRMT (0.47) | POLRMTP2RY2P2RY1P2RY11IMPDH2 | |
| SCHEMBL17453484 | 0.91 | POLRMT (0.54) | POLRMTP2RY2P2RY1P2RY11P2RX3 | |
| SCHEMBL17453487 | 0.91 | POLRMT (0.54) | POLRMTP2RY2P2RY1P2RY11P2RX3 | |
| SCHEMBL19644602 | 0.85 | P2RY1 (0.40) | POLRMTP2RY2P2RY1P2RY11IMPDH2 | |
| SCHEMBL21880598 | 0.85 | POLRMT (0.50) | POLRMTP2RY2P2RY1P2RY11P2RX3 | |
| SCHEMBL21880607 | 0.85 | POLRMT (0.50) | POLRMTP2RY2P2RY1P2RY11P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174870-B1 | THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2020-04-15 | — | — | EP | disclosed |
| US-9828388-B2 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2017-11-28 | — | — | US | disclosed |