Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19376188 | 0.90 | DGAT2 (0.85) | DGAT2 | |
| SCHEMBL19376284 | 0.88 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL19397244 | 0.85 | DGAT2 (0.80) | DGAT2 | |
| SCHEMBL19397246 | 0.84 | DGAT2 (0.77) | DGAT2 | |
| SCHEMBL20853705 | 0.84 | DGAT2 (0.66) | DGAT2 | |
| SCHEMBL19397247 | 0.77 | DGAT2 (0.78) | DGAT2 | |
| SCHEMBL17558275 | 0.76 | DGAT2 (1.00) | DGAT2 | |
| SCHEMBL19397258 | 0.76 | DGAT2 (0.64) | DGAT2 | |
| SCHEMBL19376258 | 0.75 | DGAT2 (0.85) | DGAT2 | |
| SCHEMBL17558258 | 0.75 | DGAT2 (1.00) | DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828369-B2 | Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARPE & DOHME CORP. (US) | 2017-11-28 | — | — | US | disclosed |