Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.36 |
| ▸ | FDPS | P14324 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.35 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658985 | 1.00 | MAPT (0.39) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL9160888 | 0.98 | CA1 (0.36) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL1886435 | 0.94 | MAPT (0.30) | MAPT | |
| SCHEMBL10841333 | 0.94 | MAPT (0.30) | MAPT | |
| SCHEMBL8859363 | 0.91 | CA2 (0.38) | CA2FDPSCA1DNM1 | |
| SCHEMBL11575980 | 0.91 | MAPT (0.42) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL21722523 | 0.91 | MAPT (0.42) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL21722514 | 0.91 | MAPT (0.42) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL2564972 | 0.91 | MAPT (0.42) | MAPTADH1BADH1CADH1AADH4 | |
| SCHEMBL21722662 | 0.91 | MAPT (0.42) | MAPTADH1BADH1CADH1AADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828360-B2 | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-11-28 | — | — | US | disclosed |