Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 15/20 | 0.55 |
| ▸ | CLK3 | P49761 | 15/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 15/20 | 0.55 |
| ▸ | WNT1 | P04628 | 6/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19216451 | 0.92 | CLK2 (0.57) | CLK2CLK3DYRK1AWNT1CLK1 | |
| SCHEMBL19356524 | 0.91 | CLK2 (0.54) | CLK2CLK3DYRK1AWNT1CLK1 | |
| SCHEMBL17587218 | 0.91 | CLK2 (0.61) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL19354885 | 0.88 | CLK2 (0.57) | CLK2CLK3DYRK1AWNT1CLK1 | |
| SCHEMBL17587214 | 0.87 | CLK2 (0.67) | CLK2CLK3DYRK1AWNT1CLK1 | |
| SCHEMBL19645571 | 0.87 | CLK2 (0.55) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL17587212 | 0.86 | WNT1 (0.66) | CLK2CLK3DYRK1AWNT1CLK1 | |
| SCHEMBL19363294 | 0.84 | CLK2 (0.56) | CLK2CLK3DYRK1AWNT1CLK1 | |
| SCHEMBL17587204 | 0.84 | CLK2 (0.69) | CLK2CLK3DYRK1AWNT1CLK1 | |
| SCHEMBL19645556 | 0.84 | CLK2 (0.53) | CLK2CLK3DYRK1AWNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828372-B2 | 2-(1H-indazol-3-yl)-1H-imidazo[4,5-C]pyridine and therapeutic uses thereof | SAMUMED, LLC (US) | 2017-11-28 | — | — | US | disclosed |