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Sugi Predict / Targets / WNT1

WNT1

Proto-oncogene Wnt-1 · P04628 · WNT1 on Sugi Atlas →

91,494 patent compounds predicted against WNT1, 63,724 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL559231 SCHEMBL559231 0.79 19/20
SCHEMBL1225926 SCHEMBL1225926 0.68 14/20
SCHEMBL559440 SCHEMBL559440 0.55 14/20
SCHEMBL82655 SCHEMBL82655 0.70 13/20
SCHEMBL558791 SCHEMBL558791 0.65 13/20
SCHEMBL951209 SCHEMBL951209 0.54 13/20
SCHEMBL955157 SCHEMBL955157 0.54 13/20
SCHEMBL560192 SCHEMBL560192 0.52 13/20
SCHEMBL82407 SCHEMBL82407 0.66 12/20
SCHEMBL559264 SCHEMBL559264 0.56 12/20
SCHEMBL81513 SCHEMBL81513 0.55 12/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL951130) 0.55 12/20
SCHEMBL559169 SCHEMBL559169 0.73 11/20
SCHEMBL83645 SCHEMBL83645 0.63 11/20
SCHEMBL558193 SCHEMBL558193 0.63 11/20
SCHEMBL955986 SCHEMBL955986 0.59 11/20
SCHEMBL559512 SCHEMBL559512 0.52 11/20
SCHEMBL559080 SCHEMBL559080 0.51 11/20
SCHEMBL82928 SCHEMBL82928 0.71 10/20
SCHEMBL952067 SCHEMBL952067 0.54 10/20

Clinical trials — most relevant to WNT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment PHASE2/PHASE3RECRUITING
Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation PHASE2WITHDRAWN
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy PHASE2RECRUITING
A Phase II Trial Evaluating WNT974 in Patients With Metastatic Head and Neck Squamous Cell Carcinoma PHASE2WITHDRAWN
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer PHASE2ACTIVE_NOT_RECRUITING
Mesalazine Effects in Sporadic Colorectal Adenoma Patients PHASE2COMPLETED
A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors PHASE1RECRUITING
Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of XNW7201 in Subjects With Advanced Solid Tumors PHASE1COMPLETED
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma PHASE1COMPLETED
Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma PHASE1RECRUITING
Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC) PHASE1COMPLETED
A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands PHASE1COMPLETED
Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma EARLY_PHASE1RECRUITING
Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors nanNO_LONGER_AVAILABLE
Eosinophil Induced Remodelling in Asthma nanCOMPLETED
Klotho _ LRP-6 _ Gastric Adenocarcinoma nanUNKNOWN
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins nanCOMPLETED
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment nanCOMPLETED
LEF1 EXPRESSION IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: A MARKER FOR DIAGNOSIS AND SURVIVAL PREDICTION nanRECRUITING
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling nanCOMPLETED
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients nanUNKNOWN
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury nanUNKNOWN
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma. nanRECRUITING
Tension-Type Headache Gene Expression and Methylation nanAVAILABLE
Peripheral Blood Stem Cells Obtained From Normal Volunteers for Studying Retroviral Vector Mediated Gene Transfer Into Primitive Hematopoietic Cells and Vector Mediated Transgene Expression in Mature Hematopoietic Lineages nanCOMPLETED
Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma nanACTIVE_NOT_RECRUITING
CTNNB1 Neurodevelopmental Syndrome - Natural History Study nanRECRUITING
Diagnostic and Therapeutic Targets in Cartilaginous Tumours nanRECRUITING
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis nanRECRUITING
CircularRNA-microRNA-mRNA Regulatory Axis in IVF nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a WNT1 binder may also engage these)

ProteinNameSimilarity
P04426 — 1.000 P04426 →
Q91029 — 0.996 Q91029 →
P24257 — 0.994 P24257 →
P49893 — 0.991 P49893 →
P48614 — 0.990 P48614 →
O00744 — 0.990 O00744 →
P56705 — 0.989 P56705 →
P22724 — 0.988 P22724 →
Q9QXQ5 — 0.988 Q9QXQ5 →
Q9Y6F9 — 0.986 Q9Y6F9 →
Q801F7 — 0.986 Q801F7 →
Q5NVK2 — 0.985 Q5NVK2 →
Q9H1J7 — 0.983 Q9H1J7 →
Q28J82 — 0.983 Q28J82 →
Q66II0 — 0.982 Q66II0 →
P22727 — 0.981 P22727 →
Q2QLC7 — 0.981 Q2QLC7 →
P48615 — 0.980 P48615 →
P49340 — 0.980 P49340 →
Q93097 — 0.980 Q93097 →
O96014 — 0.979 O96014 →
O70283 — 0.978 O70283 →
Q07DZ8 — 0.978 Q07DZ8 →
P21551 — 0.977 P21551 →
Q07E18 — 0.977 Q07E18 →
Q2QL85 — 0.977 Q2QL85 →
Q2IBG1 — 0.977 Q2IBG1 →
O73864 — 0.976 O73864 →
O42122 — 0.976 O42122 →
P22726 — 0.976 P22726 →