Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20687420 | 0.89 | CFD (0.40) | CFDCHRM1 | |
| SCHEMBL19968249 | 0.84 | CHRM3 (0.39) | GSK3AGSK3BCFDHTR1AHTR7 | |
| SCHEMBL17039238 | 0.80 | CFD (0.37) | GSK3AGSK3BCFDHTR1AHTR7 | |
| SCHEMBL18576410 | 0.73 | CFD (0.40) | CFDCHRM2CHRM1CHRM3 | |
| SCHEMBL18572911 | 0.73 | CFD (0.40) | CFDCHRM2CHRM1CHRM3 | |
| SCHEMBL17034800 | 0.73 | CFD (0.40) | CFDCHRM2CHRM1CHRM3 | |
| SCHEMBL20329696 | 0.72 | CFD (0.41) | CFDCHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL29545426 | 0.72 | CFD (0.40) | CFDCHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL17023486 | 0.72 | CFD (0.40) | CFDCHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL18548455 | 0.72 | CFD (0.40) | CFDCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828396-B2 | Alkyne compounds for treatment of complement mediated disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-11-28 | — | — | US | disclosed |