Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.43 |
| ▸ | JAK1 | P23458 | 16/20 | 0.43 |
| ▸ | JAK3 | P52333 | 16/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384364 | 1.00 | JAK2 (0.43) | JAK2JAK1JAK3DGAT1PDE10A | |
| SCHEMBL2384374 | 1.00 | JAK2 (0.43) | JAK2JAK1JAK3DGAT1PDE10A | |
| SCHEMBL1371116 | 0.93 | JAK2 (0.50) | JAK2JAK1JAK3DGAT1PDE10A | |
| SCHEMBL2385140 | 0.91 | JAK2 (0.54) | JAK2JAK1JAK3DGAT1 | |
| SCHEMBL2385148 | 0.91 | JAK2 (0.54) | JAK2JAK1JAK3DGAT1 | |
| SCHEMBL17403295 | 0.90 | JAK1 (0.40) | JAK2JAK1JAK3DGAT1 | |
| SCHEMBL2385721 | 0.90 | JAK2 (0.43) | JAK2JAK1JAK3DGAT1 | |
| SCHEMBL2386433 | 0.89 | DGAT1 (0.40) | JAK2JAK1JAK3DGAT1 | |
| SCHEMBL2386430 | 0.89 | DGAT1 (0.40) | JAK2JAK1JAK3DGAT1 | |
| SCHEMBL12449399 | 0.88 | JAK2 (0.53) | JAK2JAK1JAK3DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9827244-B2 | Cap/endo dual inhibitors and their use in the treatment, amelioration or prevention of a viral disease | F. HOFFMANN-LA ROCHE AG (CH) | 2017-11-28 | — | — | US | disclosed |