Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16680219 | 0.75 | CYP1A2 (0.52) | CYP1A2GAASMN1; SMN2CYP19A1LMNA | |
| SCHEMBL944219 | 0.72 | CYP1A2 (0.63) | CYP1A2GAASMN1; SMN2LMNAPOLB | |
| SCHEMBL914646 | 0.71 | GAA (0.54) | CYP1A2GAASMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL11637319 | 0.69 | SMN1; SMN2 (0.57) | CYP1A2GAASMN1; SMN2CYP19A1NPSR1 | |
| SCHEMBL4326710 | 0.68 | SMN1; SMN2 (0.58) | CYP1A2GAASMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL4727523 | 0.68 | GAA (0.46) | CYP1A2GAASMN1; SMN2LMNAPOLB | |
| SCHEMBL915213 | 0.68 | MEN1 (0.64) | GAASMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL474857 | 0.68 | CYP1A2 (1.00) | CYP1A2GAASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9445618 | 0.68 | SMN1; SMN2 (0.51) | CYP1A2GAASMN1; SMN2CYP19A1LMNA | |
| SCHEMBL18534510 | 0.68 | MEN1 (0.54) | CYP1A2GAASMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846804-B1 | TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME (US) | 2017-11-29 | — | — | EP | disclosed |