Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.75 |
| ▸ | LCK | P06239 | 6/20 | 0.74 |
| ▸ | EGFR | P00533 | 5/20 | 0.74 |
| ▸ | ITK | Q08881 | 3/20 | 0.74 |
| ▸ | LYN | P07948 | 2/20 | 0.74 |
| ▸ | SRC | P12931 | 2/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.74 |
| ▸ | YES1 | P07947 | 1/20 | 0.74 |
| ▸ | HCK | P08631 | 1/20 | 0.74 |
| ▸ | FGR | P09769 | 1/20 | 0.74 |
| ▸ | FER | P16591 | 1/20 | 0.74 |
| ▸ | CSK | P41240 | 1/20 | 0.74 |
| ▸ | TEC | P42680 | 1/20 | 0.74 |
| ▸ | BLK | P51451 | 1/20 | 0.74 |
| ▸ | BMX | P51813 | 1/20 | 0.74 |
| ▸ | JAK3 | P52333 | 1/20 | 0.74 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.74 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19649196 | 0.88 | BTK (0.78) | BTKLCKEGFRITKLYN | |
| SCHEMBL17951813 | 0.85 | BTK (1.00) | BTKLCKEGFRITKLYN | |
| SCHEMBL2631407 | 0.85 | BTK (0.84) | BTKLCKEGFRITKLYN | |
| SCHEMBL15915382 | 0.85 | BTK (0.84) | BTKLCKEGFRITKLYN | |
| SCHEMBL30586962 | 0.85 | BTK (1.00) | BTKLCKEGFRITKLYN | |
| SCHEMBL6431516 | 0.85 | BTK (1.00) | BTKLCKEGFRITKLYN | |
| SCHEMBL23223108 | 0.85 | BTK (0.75) | BTKLCKEGFRITKLYN | |
| SCHEMBL201745 | 0.85 | BTK (1.00) | BTKLCKEGFRITKLYN | |
| SCHEMBL410198 | 0.85 | BTK (0.80) | BTKLCKEGFRITKLYN | |
| SCHEMBL201744 | 0.85 | BTK (1.00) | BTKLCKEGFRITKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3248979-B1 | NOVEL INHIBITOR OF FLT3 KINASE AND USE THEREOF | HEFEI INST PHYSICAL SCI CAS (CN) | 2021-04-14 | — | — | EP | disclosed |
| EP-3248979-A1 | NOVEL INHIBITOR OF FLT3 KINASE AND USE THEREOF | Hefei Institutes of Physical Sicence, Chinese Academy of Sciences (CN) | 2017-11-29 | — | — | EP | disclosed |