SCHEMBL1964996

SCHEMBL1964996

CC(C)(C)OC(=O)N(CO[Si](C)(C)C(C)(C)C)C1CC(O)C1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
ASGR1 P07306 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5027219 0.74
SCHEMBL30752679 0.72 PPM1D (0.36)
SCHEMBL13052385 0.69 PPM1D (0.32)
SCHEMBL17184415 0.69 HSD11B1 (0.44) CHRM2CHRM1CHRM3ASGR1
SCHEMBL13567986 0.69 HSD11B1 (0.44) CHRM2CHRM1CHRM3ASGR1
SCHEMBL13567993 0.69 HSD11B1 (0.44) CHRM2CHRM1CHRM3ASGR1
SCHEMBL13052389 0.68 CHRM2 (0.34) CHRM2CHRM1CHRM3ASGR1
SCHEMBL14327679 0.68 CHRM2 (0.34) CHRM2CHRM1CHRM3ASGR1
SCHEMBL5029566 0.67
SCHEMBL24438514 0.66 CHRM2 (0.45) CHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582660-A1 NEW CATHEPSIN S PROTEASE INHIBITORS, USEFUL IN THE TREATMENT OF E.G. AUTOIMMUNE DISORDERS, ALLERGY AND CHRONIC PAIN CONDITIONS Medivir UK Ltd (GB) 2013-04-24 EP disclosed
EP-2509957-A1 CYSTEINE PROTEASE INHIBITORS Medivir UK Ltd (GB) 2012-10-17 EP disclosed
WO-2011158197-A1 NEW CATHEPSIN S PROTEASE INHIBITORS, USEFUL IN THE TREATMENT OF E.G. AUTOIMMUNE DISORDERS, ALLERGY AND CHRONIC PAIN CONDITIONS MEDIVIR UK LIMITED (GB) 2011-12-22 WO disclosed
EP-2358692-A1 CYSTEINE PROTEASE INHIBITORS Medivir UK Ltd (GB) 2011-08-24 EP disclosed
WO-2011070541-A1 CYSTEINE PROTEASE INHIBITORS MEDIVIR UK LIMITED (GB) 2011-06-16 WO disclosed
WO-2010070615-A1 CYSTEINE PROTEASE INHIBITORS MEDIVIR UK LTD (GB) 2010-06-24 WO disclosed