Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.59 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | MARK3 | P27448 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.55 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966831 | 0.88 | S1PR1 (0.58) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL3741047 | 0.84 | S1PR1 (0.73) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL13045365 | 0.81 | S1PR1 (0.64) | S1PR1MAP4K4MINK1S1PR3PRKCD | |
| SCHEMBL1965044 | 0.80 | S1PR1 (0.66) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL3746333 | 0.80 | MAP4K4 (0.63) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL1843853 | 0.79 | S1PR1 (0.69) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL3741171 | 0.79 | MAP4K4 (0.65) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL398987 | 0.79 | S1PR1 (1.00) | S1PR1MAP4K4MINK1S1PR3S1PR5 | |
| SCHEMBL403510 | 0.79 | S1PR1 (0.78) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL400101 | 0.79 | S1PR1 (0.78) | S1PR1MAP4K4MINK1S1PR3DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509424-A1 | NOVEL OXADIAZOLE COMPOUNDS | Abbott Laboratories (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071570-A1 | NOVEL OXADIAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-16 | — | — | WO | disclosed |