Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657118 | 0.85 | MAPT (0.55) | HSP90AA1HSP90AB1HTTHPGDSMN1; SMN2 | |
| SCHEMBL17796530 | 0.81 | HPGD (0.56) | HSP90AA1HTTHPGDCNR2SMN1; SMN2 | |
| SCHEMBL10255135 | 0.78 | SMN1; SMN2 (0.65) | HSP90AA1HSP90AB1HTTHPGDSMN1; SMN2 | |
| SCHEMBL19651851 | 0.75 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1HTTHPGDSMN1; SMN2 | |
| SCHEMBL8819862 | 0.75 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1HTTHPGDSMN1; SMN2 | |
| SCHEMBL5079739 | 0.75 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HTTHPGDSMN1; SMN2 | |
| SCHEMBL19651862 | 0.73 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1HTTHPGDSMN1; SMN2 | |
| SCHEMBL19706323 | 0.73 | GABRP (0.58) | HPGDPKMALDH1A1MAPTTSHR | |
| SCHEMBL12545691 | 0.72 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1HTTHPGDCNR1 | |
| SCHEMBL12141974 | 0.72 | SMN1; SMN2 (0.53) | HSP90AA1HSP90AB1HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRPF3 | HSP90AA1 1632/4885HSP90AB1 1054/4885HTT 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.