Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DDX3X | O00571 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806336 | 0.85 | P2RX7 (0.34) | SIRT2FLT4L3MBTL1DDX3XKDM4E | |
| SCHEMBL13128614 | 0.76 | BDKRB1 (0.37) | DDX3XKDM4EAURKAALDH1A1 | |
| SCHEMBL2811328 | 0.76 | MEN1 (0.40) | SIRT2DDX3XKDM4EAURKAALDH1A1 | |
| SCHEMBL185111 | 0.74 | CNR2 (0.36) | MAPK1AURKA | |
| SCHEMBL2814182 | 0.74 | SIRT2 (0.35) | SIRT2FLT4L3MBTL1DDX3XPTK2 | |
| SCHEMBL2805177 | 0.73 | P2RX7 (0.35) | SIRT2FLT4L3MBTL1DDX3XKDM4E | |
| SCHEMBL2811659 | 0.73 | P2RX7 (0.40) | FLT4LMNADDX3XAURKA | |
| SCHEMBL13160220 | 0.73 | — | — | |
| SCHEMBL2782634 | 0.73 | MEN1 (0.39) | SIRT2FLT4DDX3XKDM4EAURKA | |
| SCHEMBL2814184 | 0.72 | P2RX7 (0.33) | SIRT2FLT4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |