Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | JAK1 | P23458 | 7/20 | 0.38 |
| ▸ | JAK3 | P52333 | 7/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28089932 | 0.83 | SYK (0.38) | SYK | |
| SCHEMBL10002324 | 0.81 | PARP1 (0.42) | SYKPKN1PKN2 | |
| SCHEMBL21024040 | 0.81 | CREBBP (0.39) | SYKCREBBPJAK2JAK1JAK3 | |
| SCHEMBL19657744 | 0.81 | CREBBP (0.37) | SYKCREBBPJAK2JAK1JAK3 | |
| SCHEMBL9898861 | 0.77 | SYK (0.36) | SYKCREBBPJAK2JAK1JAK3 | |
| SCHEMBL19657577 | 0.77 | NR1I2 (0.42) | SYKCREBBPPKN1PKN2NR1I2 | |
| SCHEMBL19657319 | 0.77 | SYK (0.53) | SYKJAK2JAK1JAK3 | |
| SCHEMBL29984777 | 0.77 | SYK (0.36) | SYKCREBBPJAK2JAK1JAK3 | |
| SCHEMBL19657559 | 0.73 | SYK (0.42) | SYKCREBBPNR1I2AHR | |
| SCHEMBL27409261 | 0.72 | PDK2 (0.43) | SYKCREBBPNR1I2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |