Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22822792 | 0.83 | CREBBP (0.41) | ALDH1A1GLAPKMHPGDBRD4 | |
| SCHEMBL19657311 | 0.82 | BRD4 (0.48) | ALDH1A1GLAPKMHPGDBRD4 | |
| SCHEMBL19657852 | 0.80 | BRD4 (0.46) | ALDH1A1GLAPKMHPGDBRD4 | |
| SCHEMBL19657300 | 0.78 | BRD4 (0.43) | ALDH1A1GLAPKMHPGDBRD4 | |
| SCHEMBL19657314 | 0.78 | CREBBP (0.44) | ALDH1A1GLAPKMHPGDBRD4 | |
| SCHEMBL1003770 | 0.72 | PLK1 (0.54) | ALDH1A1HPGDKDM4EPLK1POLB | |
| SCHEMBL19657565 | 0.72 | NR4A2 (0.68) | BRD4CREBBPKDM4ENR4A2POLB | |
| SCHEMBL19657743 | 0.71 | BRD4 (0.46) | ALDH1A1GLAPKMHPGDBRD4 | |
| SCHEMBL19657313 | 0.71 | CREBBP (0.49) | BRD4CREBBPNR4A2 | |
| SCHEMBL7860722 | 0.71 | PLK1 (0.56) | ALDH1A1PLK1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |