Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657743 | 0.85 | BRD4 (0.46) | BRD4NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL19657852 | 0.85 | BRD4 (0.46) | BRD4NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL22822275 | 0.84 | BRD4 (0.44) | BRD4NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL19657300 | 0.82 | BRD4 (0.43) | BRD4NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL19657307 | 0.82 | ALDH1A1 (0.44) | BRD4NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL21024059 | 0.82 | BRD4 (0.43) | BRD4NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL19657314 | 0.82 | CREBBP (0.44) | BRD4NR4A2CREBBPALDH1A1KDM4E | |
| SCHEMBL23809451 | 0.82 | KDM4E (0.44) | ALDH1A1KDM4EL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL19657565 | 0.76 | NR4A2 (0.68) | BRD4NR4A2CREBBPKDM4EL3MBTL1 | |
| SCHEMBL19657313 | 0.76 | CREBBP (0.49) | BRD4NR4A2CREBBPBAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |